This volume fills a gap in studies of literature, media, culture, and art by exploring depictions of contagious diseases in different genres since the dawn of humanity and compiling a history of such representations of pestilence from a post-human and environmental perspective. Indulging in humankind’s struggle with calamities throughout history, the collection discusses several media that portray real or imagined futures based on past and present facts. In today’s world, which is stricken with global warming and the COVID-19 pandemic, these narratives, termed ‘plague literature’, hold a crucial position in guiding humanity towards a greater ecological awareness. The book will appeal to scholars, students, organisations, and individuals who are interested in studies of literature, history, media, art, and environmental humanities.