Dr Leandro Bueno Bergantin received his PhD from the Universidade Federal de São Paulo, Brazil, in 2014. His research involves cell signaling mediated by calcium ions, including its role in neuropsychopharmacology, autonomic and cardiovascular pharmacology, and cancer, and his studies have solved the enigma of the paradoxical effects produced by L-type calcium ion channel blockers. He has published over sixty articles in international journals, in addition to several book chapters, and is the author of a book. He is a member of the editorial boards of numerous international journals, and has participated in many international conferences.Dr Afonso Caricati-Neto graduated in Biomedicine from Universidade Estadual Paulista, Brazil, in 1984, and received his MSc and PhD from Universidade Federal de São Paulo, Brazil, in 1989 and 1996. He has been Associate Professor at the Department of Pharmacology of Universidade Federal de São Paulo since 1989 and an Associate Researcher at Instituto Teófilo Hernando at Universidad Autónoma de Madrid since 2001. His research involves the pharmacology of drug receptors and intracellular signalling systems, and their role in physiological and pathological processes. He has published 150 scientific articles, 13 book chapters and one book on this subject.