Vincent Laudet, PhD, is Professor of Biology at the École Normale Supérieure de Lyon at the Institut de Génomique Fonctionelle de Lyon (CNRS UMR 5242), France, where he is the leader of the research team working on the evolution of nuclear hormone receptors.
After studying molecular biology in Montpellier and Strasbourg, he started research working on the v-erbA oncogene in Dominique Stéhelin's laboratory at the Pasteur Institute of Lille, France. V-erbA turns out to be a viral counterpart of the thyroid hormone receptor a gene and this was the start of his interest in nuclear hormone receptors. Having a constant interest in molecular evolution and natural history, he started an evolutionary analysis of nuclear hormone receptors. Vincent obtained his PhD degree in 1992 and was established as a group leader in 1994. He moved in 1997 to the Ecole Normale Supérieure de Lyon as a full Professor. He became Director of the Institute of Functional Genomics of Lyon from 2008 to 2015. Then he moved to Banyuls-sur-mer in the south of France where he was appointed as the head of the Oceanologic Observatory in 2015.
Vincent performed the first evolutionary analysis of the nuclear hormone receptor (NR) superfamily showing that there was no relationship between ligand specificity and phylogenetic relatedness. His laboratory then focused on three directions, both related to the field on NR evolution: (i) the study of the implication of RARs, RXRs and TRs in the evolutionary process essentially through Evo/Devo studies using amphioxus as a marine biology model organism; (ii) the study of the evolution of ligand-binding abilities of various NRs and the origin of NR ligands; and (iii) the interplay between NRs and the effects of environmental pollutants such as bisphenol A for which his lab recently demonstrated that the orphan nuclear receptor ERRg is an in vivo receptor.
Since 2015 he has been the director of the marine station of Banyuls-sur-mer, where he is currently developing coral reef fish and in particular the clownfish Amphiprion ocellaris as a marine model organism for Eco/Evo/Devo studies. His group focuses on the evolution of life history strategies of these fish, in particular the recruitment of fish larvae to the reef, which corresponds to a real metamorphosis and how hormones (thyroid hormones, corticoids) control this process. His group also analyzes how anthropogenic stressors (pollutants, temperature rise, acidification) interfere with this process which is critical for the survival of coral reef populations.
Vincent’s laboratory has contributed to more than 200 scientific papers and 40 reviews (h-index: 70), including two books in molecular endocrinology, molecular evolution, genomics and developmental biology.