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Dr Kishore Guda

Cancer Research

Case Western Reserve University

Dr Kishore Guda is an Assistant Professor at the Case Western Reserve University Comprehensive Cancer Center, USA. He holds a Doctorate degree in Veterinary Medicine (DVM) and a PhD in Cellular and Molecular Pharmacology. Kishore’s laboratory conducts translational cancer research, particularly focusing on gastrointestinal malignancies, with a long-term objective of developing molecular biomarkers and targeted therapies for colon and esophageal cancers.

His prior contributions have led to several high-impact advances in the field of cancer genetics, particularly including: the first proof that genetic defects in glycosylation and prostaglandin pathways confer risk for developing colorectal cancer in humans, thereby uncovering novel key genetic risk factors for inherited susceptibility to colorectal cancer and providing the first and strong exemplars for the “rare variant – large effect” model of colorectal cancer susceptibility; the first evidence demonstrating the contribution of genetic differences to ethnicity-associated disparities in colorectal cancer burdens; discovery of the first germline mutation underlying the genetic basis for the syndrome of familial Barrett’s esophagus and esophageal adenocarcinoma; discovery of novel small and large non-coding RNA biomarkers, gene-fusions, and oncogenic pathways associated with esophageal adenocarcinoma progression, unraveling key driver mechanisms and novel druggable therapeutic targets in the esophageal adenocarcinoma disease model; and development of novel informatics tools and methodologies for assessing genomic aberrations using high-throughput “omics” datasets.

Kishore’s laboratory uses a wide array of cutting-edge biomedical approaches including molecular genetics, animal models, high-throughput genomics, systems biology/bioinformatics etc. for their studies, and is currently supported through several NIH/NCI program project grants.