This book shows that Eugene O’Neill’s modern American drama is a survey on the politics of desire, the power of doom, and the variable configurations of the polis. It highlights that the modern American city, or polis, is the stage on which the antithetic categories of doom and desire are re-enacted in different undertones. The text notes that desire, doom, schizophrenia, and the archeology of the polis are reconceived by the playwright, while legacy, sexuality, lucre, and the volatility of the free flow of capital entrap the American subject in a maze of qualms and queries. Subjection and resistance give birth to schizorevolutionary subjects, seeking lines of flight. Indeed, as noted here, O’Neill’s plays portray their protagonists as desiring machines, trying to evade the modern closed circles of power, and various modes of becoming, to use Gilles Deleuze’s concept. O’Neill encounters Deleuze at the level of thoughts and sensations, anticipating postmodern plateaus for the human subject to grow into a rhizome.