David  M. Wilson

David M. Wilson

Biochemistry

National Institute on Aging

David M. Wilson III received a Bachelor of Arts in both Biology and Political Science from Bucknell University, USA. He completed his PhD work as part of the Molecular Biology Program at Loyola University of Chicago – Stritch School of Medicine, studying repair processes for alkylative and oxidative DNA damage. Dr Wilson performed his postdoctoral training at Harvard School of Public Health in the Department of Molecular and Cellular Toxicology, investigating the molecular mechanisms of abasic endonucleases and the base excision repair pathway. Subsequently, he was a Senior Biomedical Scientist at Lawrence Livermore National Laboratory, USA, in the Biology and Biotechnology Research Program, where he continued his work on mammalian DNA repair with an emphasis on nucleases. Dr Wilson is currently a tenured Senior Investigator at the National Institute on Aging in Baltimore, USA, in the Laboratory of Molecular Gerontology. His efforts (in collaboration with many colleagues) have been instrumental in defining how specific DNA repair proteins operate mechanistically and participate in the etiology of certain hereditary disorders, particularly those with neurological abnormalities and premature aging phenotypes. Additional investigations have included evaluating the consequence of amino acid variation in DNA repair proteins on functional capacity and disease (e.g. cancer) susceptibility, designing DNA repair capacity assays for assessing repair potential among individuals in the population, and identifying small molecule DNA repair modulators towards the development of novel therapeutics.