George Washington School of Medicine & Health Sciences
Dr Pedro A. Jose is Professor of Medicine and Pharmacology and Physiology at the George Washington School of Medicine & Health Sciences, USA, Visiting Professor at Third Military Medical University, China, and at the Anhui Institute of Cardiovascular Disease, China, and Concurrent Professor at Nanjing University School of Medicine, China. He is also a guest lecturer at several universities and learned societies in the USA and many other countries around the world. Pedro received his MD degree, magna cum laude, meritissimus, from the University of Santo Tomas, Philippines, and placed first in the Philippine National Board Examinations in Medicine and Surgery. He received his PhD degree in Physiology from Georgetown University, USA, and defended his dissertation with distinction. He is a past President of the American Society of Pediatric Nephrology. The primary goal of his research is to determine the genetic and pharmacogenetic bases of human essential hypertension and the metabolic syndrome. Specifically, the mission of his laboratory is to study the role of dopamine, adrenergic, and angiotensin receptor subtypes and dopamine regulatory genes (e.g., G protein-coupled receptor kinase 4 [GRK4], sorting nexins, gastrin) on sodium transport in specific nephron segments and their roles in the pathogenesis of genetic hypertension and metabolic syndrome. Pedro's studies are performed in vitro and in vivo, using molecular and cell biological methods, including gene silencing, gene rescue (e.g., AAV vectors), confocal microscopy and biophysical imaging, and integrated physiology in rats, mice, and humans. He is a recognized expert on the role of dopamine receptors in the regulation of renal function, epithelial sodium transport, vascular function, and blood pressure. He has contributed novel and important information on signal transduction and cellular trafficking of dopamine receptors. He has published more than 380 scientific articles in book chapters and journals. His articles are currently cited more than 9,000 times, with 55 cited 50 or more times, 19 of which are cited more than 100 times. Four of his articles are covers of scientific journals, six are the subject of editorial commentaries, and two are featured articles. His Hirsch-index is 52. He has received several academic and research awards, including the 2003 Lewis K. Dahl Memorial Lecture (American Heart Association), 2007 Ernest H. Starling Distinguished Lecture (American Physiological Society), 2007 MERIT award (National Institutes of Health), and 2015 Excellence Award for Hypertension Research (American Heart Association). A key finding of Pedro's research is the demonstration of the crucial role of gene variants of GRK4 in the pathogenesis and personalized treatment of hypertension. He and his associates have discovered genes that cause high blood pressure when sodium intake is excessive and more importantly, genes that cause high blood pressure when sodium intake is too low. These studies have resulted in two patents in the USA. Deciphering the role of GRK4 gene variants in the pathogenesis of human essential hypertension was the second advance and discovery cited by the Director of National Heart, Lung, and Blood Institute for its 2004 budget justification to the US Congress.